NHS Blood and Transplant says blood types most in demand are O positive, O negative and B negative
The NHS has made an urgent appeal for more blood donations at their centres in Leicester and Nottingham.
It said stocks were falling due to a high level of staff and donor illnesses, mainly linked to the rise in coronavirus cases. NHS Blood and Transplant says hospitals are still receiving the blood needed but is requesting more to ensure stocks do not fall further.The NHS said donations were usually lower in the summer, when people were busy with holidays and events.
Currently, it says the Leicester donor centre is 44% full next week, while the Nottingham donor centre is only 40% full next week.Blood is used to treat patients with cancer, blood disorders and those suffering medical trauma or undergoing surgery.Follow BBC East Midlands on
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Effects of fasudil on blood–brain barrier integrity - Fluids and Barriers of the CNSBackground Cerebral infarction accounts for 85% of all stroke cases. Even in an era of rapid and effective recanalization using an intravascular approach, the majority of patients have poor functional outcomes. Thus, there is an urgent need for the development of therapeutic agents to treat acute ischemic stroke. We evaluated the effect of fasudil, a Rho kinase inhibitor, on blood brain barrier (BBB) functions under normoxia or oxygen–glucose deprivation (OGD) conditions using a primary cell-based in vitro BBB model. Methods BBB models from rat primary cultures (brain capillary endothelial cells, astrocytes, and pericytes) were subjected to either normoxia or 6 h OGD/24 h reoxygenation. To assess the effects of fasudil on BBB functions, we evaluated real time impedance, transendothelial electrical resistance (TEER), sodium fluorescein permeability, and tight junction protein expression using western blotting. Lastly, to understand the observed protective mechanism on BBB functions by fasudil we examined the role of cyclooxygenase-2 and thromboxane A2 receptor agonist U-46619 in BBB-forming cells. Results We found that treatment with 0.3–30 µM of fasudil increased cellular impedance. Fasudil enhanced barrier properties in a concentration-dependent manner, as measured by an increased (TEER) and decreased permeability. Fasudil also increased the expression of tight junction protein claudin-5. Reductions in TEER and increased permeability were observed after OGD/reoxygenation exposure in mono- and co-culture models. The improvement in BBB integrity by fasudil was confirmed in both of the models, but was significantly higher in the co-culture than in the monoculture model. Treatment with U-46619 did not show significant changes in TEER in the monoculture model, whereas it showed a significant reduction in TEER in the co-culture model. Fasudil significantly improved the U-46619-induced TEER reduction in the co-culture models. Pericytes and astrocytes have opposite effects
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