Unlocking the potential of Reg3γ: new insights into its metabolic functions and therapeutic prospects Nature metabolic metablolicfunction therepeutic prospects insights
By Shanet Susan AlexAug 3 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Experimental & Molecular Medicine Journal, researchers evaluated the physiological roles of an antimicrobial peptide , regenerating family member gamma , and analyzed its therapeutic prospects for metabolic diseases.
Studies indicate that the gut microbiota regulates several elements of glucose regulation and energy homeostasis, and Reg3γ is a connection between metabolic control and gut microbiota. Although Reg3γ interacts with the gut microbiota and contributes to gut physiology, its function in metabolic diseases is unknown.
Additionally, the team analyzed the possibility of Reg3γ as a biomarker for metabolic illnesses and the potential of Reg3γ-reliant therapies for metabolic diseases. Reg3γ is essential for wound healing, keratinocyte differentiation, and proliferation, and IL-17-induced IL-33 controls Reg3's expression. Reduced IL-33 levels in diabetes conditions cause increased inflammation and delayed wound healing.
Prebiotics, probiotics, or fermentable fiber can alter the gut microbiota makeup, increasing Reg3γ activity and positively impacting gut function, glucose homeostasis, and obesity.
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