Unlocking the mystery of long-lasting cancer treatment uclnews NatureMedicine
, combines expertise in novel immune therapy design and state-of-the-art computational analysis to identify a genetic signature of CAR T-cells that will be the most effective in the long term.
A collaborative research team from across Great Ormond Street Hospital , the Wellcome Sanger Institute and the UCL Great Ormond Street Institute of Child Health worked with families for years after their CAR T-cell treatment as part of the CARPALL study, to begin to build a picture of why some CAR T-cells stay in the body long-term.
"We hope that our research will provide the first clue as to why some CAR T-cells last for a long time—which we know is vital for keeping children cancer-free after treatment. Ultimately, this work will help us to continue to improve this already life-changing treatment." "We are indebted to all of the children and families who make research like ours possible—it is only through their dedication that we are able to build our understanding of these new therapies and build better treatments for children across the world."The team were able to study cells from 10 children who were enrolled in a pioneering clinical trial , for up to five years after their original CAR T-cell treatment.
As part of the study, the researchers identified the key genes in CAR T-cells that appeared to enable them to persist in the body for a long time. Importantly these genes will provide a starting point for future studies to identify markers of persistence in CAR T-cell products as they are made and ultimately improve their effectiveness.
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