Research published in BMCNephrol reports that acute kidney injury is associated with pain and its duration in critically ill patients.
Thus, we hypothesized that a painful state might be conceivably associated to distant organ signaling, resulting in predisposition to AKI. Thus, the objective of this study was to explore the relationship between acute pain and AKI in a cohort of critically ill patients.This study was conducted with a retrospective cohort of adult patients admitted to the ICU of Hospital Sírio Libanês, a 480-bed tertiary hospital in São Paulo, Brazil, between 1 June 2013 and 30 June 2016.
Pain was evaluated using electronic registry data recorded every two hours by the care teams. Patients who could communicate self-rated their pain using a Numerical Verbal Scale , and those who could not communicate and/or were on mechanical ventilation were evaluated using a categorical Behavioral Pain Scale . We also examined the duration of pain with consideration of NVS scores in the presence of any value other than 0 and categorical consideration of BPS scores.
The variables of interest had continuous data categorized using the Receiver Operating Characteristic curve to determine the best accuracy against the clinical outcome , with the cutoff score for each variable determined by the highest value of the sum between sensitivity and specificity, corresponding to the point of greatest inflection of the ROC curve, with the following predictors being determined: age > 70 years, MV ≥ 3 days, NVS ≥ 3 or positive pain in BPS, pain duration > 5 days,...
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