U.S. regulators plan to decide by early July whether to change the design of COVID-19 vaccines this fall in order to combat more recent variants of the coronavirus, with hopes of launching a booster campaign by October, a top Food and Drug Administration official said on Tuesday.
also presented data at the meeting. All three companies have been testing versions of their vaccines updated to combat the BA.1 Omicron variant that led to a massive surge in infections last winter.have said that their respective redesigned vaccines generate a better immune response against BA.1 than their current shots that were designed for the original virus that emerged from China.
They have said that their new vaccines also appear to work against the more recently circulating BA.4 and BA.5 Omicron subvariants, even though that protection is not as strong as against BA.1. One issue being considered is whether the manufacturers should update their vaccines to more closely match the BA.4 and BA.5 subvariants.
Dr. Kanta Subbarao, a presenter representing a World Health Organization advisory committee that also considered the issue, suggested that BA.1-based vaccines would generate a broader immune response because that variant is more distinct from the original version than its successor subvariants. "Our goal here is to achieve broader immunity against circulating and emerging variants," Subbarao said, noting that trying to match what variant might be circulating in the fall is difficult because of uncertainty about the trajectory of the evolution of the virus.
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