To what extent does prenatal folate status modify associations between early pregnancy perfluoroalkyl and polyfluoroalkyl substance exposure and birth outcomes? JAMANetworkOpen HarvardChanSPH prenatal folate PFAS pregnancy womenshealth
By Neha MathurJun 2 2023Reviewed by Lily Ramsey, LLM In a recent article published in JAMA Network Open, researchers evaluated the relationship between perfluoroalkyl and polyfluoroalkyl substance exposure during early pregnancy and birth outcomes.
PFAS are synthetic chemicals found in nonstick cooking utensils, cosmetics, food packaging, etc., that persist in the environment and people. PFAS exposure and its presence harm a person's overall health, especially reproductive health. Since prenatal PFAS exposure is related to epigenetic changes in cord blood, good folate status might also counteract epigenetic changes through its critical methyl-donor role in DNA methylation, thus mitigating the health hazards.
Specifically for folate measurements, they interviewed all participants at the time of study recruitment to enquire about their supplement intake for the three months before pregnancy detection. They calculated Spearman correlation coefficients of six PFAS and plasma folate concentrations and DFE intake after grouping the study population by quartiles.
Results Of 14,00 pregnant women in this study cohort, 957 reported periconceptional folic acid supplement use. The study cohort characteristics were comparable across quartile groups stratified by plasma folate concentrations. However, mothers in the lowest quartile of the four DFE groups were less likely to use periconceptional folic acid supplements.
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