Age vs. genetics: Which is more important for determining how we age? NatureComms
). For a given tissue, genes were included if they had >0.1 TPM in ≥20% of samples and ≥6 reads in ≥20% of samples, following GTEx’s eQTL analysis pipeline. To compare gene expression heritability across individuals of different ages, for some analyses we split the GTEx data for each tissue into two age groups,"young" and"old," based on the median age of individuals in the full dataset, which was 55 .
We report the number of genes included in analysis for each tissue . For each gene in each tissue and each age group, we regressed the GTEx pre-normalized expression levels on the genotype of the lead SNP using 5 PCs, 15 PEER factors, sex, PCR protocol and sequencing platform as covariates, following the GTEx best practices. We confirmed our results using both our recomputed PEER factors as well as the PEER factors provided by GTEx .
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