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The study found that participants who spent more than six hours working on a tedious and mentally demanding assignment had higher levels of glutamate — an important signalling molecule in the brain — than did those who had performed easier tasks. Too much glutamate can disrupt brain function, and a rest period could allow the brain to restore proper regulation of the molecule, the authors note.
The work is important in its effort to link cognitive fatigue with neurometabolism, but more research — potentially in non-human animals — will be needed to establish a causal link, says behavioural neuroscientist Carmen Sandi at the Swiss Federal Institute of Technology in Lausanne. “It’s very good to start looking into this aspect,” she says. “But for now this is an observation, which is a correlation.
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