.DrJohnM interviews Dr Rachel Lampert of YaleCardiology about the LIVE HCM trial on vigorous exercise in patients with Hypertrophiccardiomyopathy WCCardio ACC23
Hi, everyone. This is John Mandrola from theheart.org | Medscape Cardiology, and I'm here at the American College of Cardiology meeting. I'm really pleased to be with one of my friends, Rachel Lampert, who's a professor of medicine and electrophysiology at Yale University. She's here to present the
What we did in this study was –that we found individuals with HCM aged 8-60 years, and we enrolled people across the spectrum of exercise. So we enrolled individuals who were vigorous exercisers, even competitive athletes; those doing moderate amounts of exercise; and those who were sedentary and had less active lifestyles.
We looked at some subgroups, including persons who were more competitive among the vigorous exercise group. We looked at those who had only overt HCM. This study did enroll patients who had genetic variants for HCM without yet having expressed the disease. That accounted for 8% of our population. When we looked at the group without those, we basically had the same finding. The CIs were a bit wider, because it was a smaller group, but the hazard ratio was very similar.
So where that left us was, if you have HCM and a defibrillator, you're safe to be more vigorous. But if you are lower-risk and don't have a need a defibrillator, then you're still restricted, which really didn't make sense to me or to patients. We knew that we needed to figure this out for HCM in general so that we can advise our patients who are lower-risk whether they can participate as well in vigorous exercise.
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