It's a global pandemic. The year is not 2020 but 1918, and Harriet Jane Lawrence is developing a vaccine against the deadliest influenza outbreak the world has ever seen
Harriet Jane Lawrence was one of the first female pathologists in the U.S. In the early 1900s she worked in Portland, Ore., where she hunted microbes and developed vaccines and serum therapies with the help of 200 guinea pigs that she kept in her garage. Her work on a vaccine during the 1918 influenza pandemic earned her presidential recognition and has had a lasting impact on medicine.Lost Women of Science is produced for the ear.
Erica Huang: This is something that is mentioned constantly in the records I’ve found about Lawrence. Guinea pigs.Erica Huang: That she kept in her garage at her house in Portland, and used literally as guinea pigs – to develop vaccines and serum therapies.Let’s go back a bit. Erica Huang: But even though there had been some amazing advances in immunology, and vaccines and antitoxins had been developed to treat some diseases like diphtheria and tetanus, there was still a lot they didn’t know. Most importantly:Erica Huang: Bacteria and viruses are fundamentally different. Bacteria are larger, single cells that can survive on their own. Viruses are much smaller, and they cause infection by entering and multiplying inside the host’s healthy cells.
Michael Worobey: The vast majority of people who died from flu, died of secondary bacterial pneumonia. So, was this work in vain? No! It wasn’t a perfect solution, but it most likely saved lives. And also, the vaccines that were created to fight pneumonia during that time, are still helping us out today.
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