Introducing our favourite TikTok trend, the vanilla girl aesthetic ✨
of views last year. Now, the vanilla girl aesthetic has come to swipe the top spot as we head into 2023.
So what is a “vanilla girl”? The aesthetic leans into luxe, cosy minimalism. It's heavy on easy-going outfits in cosy, tactile textures and airy, neutral colours like white, beige, cream and, well, vanilla. Linen shirts are slung over soft bed shorts, cashmere cardigans are draped over pointelle vest tops and lacy bralettes peek out from beneath cosy knits. Beauty-wise, makeup is kept natural, fresh and pretty.
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Introducing micro physiological systems to evaluate new radiopharmaceuticals: A binding study with radiolabeled cetuximabRadiopharmaceuticals can be used for targetspecific functional diagnostics, such as PET or SPECT imaging, or radionuclide therapy of diseased tissue, depending on the incorporated radionuclide. Following initial in vitro testing, radiopharmaceutical candidates are usually further characterized in small animals. Since reduction, replacement and refinement (3R) of animal testing is a central precept in preclinical research it would be beneficial to replace at least some of these tests by alternative methods. Using micro physiological system technology, various organ-on-chip models can be created with human cell systems/organoids, which are operated in a circulatory system under defined physiological conditions. Here we present first attempts to introduce micro physiological systems for evaluating radiopharmaceuticals using the radiolabeled anti-EGFR antibody cetuximab as reference compound. In a micro physiological system equipped with six 96-well plate-like microwells in a flow chamber, binding of 64Cu and 68Ga-labeled cetuximab to cells and spheroids grown from A431 (EGFR-positive) and MDA-MB435S (EGFR-negative) cells was measured and compared to conventional microplates. Specific saturation binding of radiolabeled cetuximab at increasing concentrations was analyzed using a phosphor imaging system. The affinity of radiolabeled cetuximab towards A431 spheroids measured in the micro physiological system was in the same range as that of the spheroids in conventional microplates. Within the assays in micro physiological systems, the results showed a trend towards increased affinity for A431 monolayers compared to the spheroids. The values of binding capacity for radiolabeled cetuximab on 2D and 3D A431 cell culture models were in the same order of magnitude when measured in micro physiological systems or in microplates. Building on these first promising results, the work will continue on MPS modules containing advanced human spheroid/ organoid models.
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Rise of the natural red pigment ‘prodigiosin’ as an immunomodulator in cancer - Cancer Cell InternationalCancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural products are interesting repository of bioactive molecules, especially those with anticancer activities. Prodigiosin, a red pigment produced by Serratia marcescens, possesses inherent anticancer characteristics, showing interesting antitumour activities in different cancers (e.g., breast, gastric) with low or without harmful effects on normal cells. The present review discusses the potential role of prodigiosin in modulating and reprogramming the metabolism of the various immune cells in the TME, such as T and B lymphocytes, tumour-associated macrophages (TAMs), natural killer (NK) cells, and tumour-associated dendritic cells (TADCs), and myeloid-derived suppressor cells (MDSCs) which in turn might introduce as an immunomodulator in cancer therapy.
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Maya Jama in emotional look back as she shows off natural look in South AfricaThe TV and radio presenter touched down in South Africa over the weekend ahead of the new winter edition of Love Island
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Christine Quinn gives rare glimpse of her natural hair in extensions-free snapNetflix favourite and Selling Sunset icon Christine Quinn shows off her real hair texture as she dials down the glamour on a sunshine trip to St Barts
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