Lab animals have long borne the brunt of drug safety trials. A new law allows drugmakers to use miniature tissue models or 'organs on chips' instead.
While alternative methods are promising, they’re still relatively new. Methods for developing organ chips, organoids, and computer models also vary from lab to lab, making it difficult to draw broad conclusions about their accuracy.
Emulate scientists recently performed a blind test on the company’s liver chip of 27 drugs, some known to be toxic to the liver and some safe. They found that the chip correctly identified 87 percent of the drugs that cause liver injury in patients, and did not falsely identify any drugs as toxic. Ewart says previous animal tests, used as a comparison, did not always predict safety issues. “In some cases, the animal models didn't fully inform the investigator of the true outcome,” she says.
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