C. diff might not originate from external transmission but rather from within the infected patient themselves. Hospital staff dedicate significant effort to safeguard patients from infections during their hospital stay. Through practices ranging from hand cleanliness to the use of isolation rooms a
C. diff is a bacterium that causes severe diarrhea and colitis . Despite rigorous infection prevention methods, hospital-onset infections, primarily C. diff, persist. A new study reveals the transmission may be more related to patient characteristics and colonization rather than direct hospital transmission.
The study team, led by Evan Snitkin, Ph.D. and Vincent Young, M.D., Ph.D., both members of the Departments of Microbiology & Immunology and Internal Medicine/Infectious Diseases at the University of Michigan Medical School and Mary Hayden, M.D.
Essentially, there was very little evidence that the strains of C. diff from one patient to the next were the same, which would imply in-hospital acquisition. In fact, there were only six genomically supported transmissions over the study period. Instead, people who were already colonized were at greater risk of transitioning to infection.
Where did the C. diff come from? “They are sort of all around us,” said Young. “C. diff creates spores, which are quite resistant to environmental stresses including exposure to oxygen and dehydration…for example, they are impervious to alcohol-based hand sanitizer.”
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