A Review published in the Journal of Translational Medicine discusses the roles of dietary lipids and lipidomics in glucose homeostasis, development, and progression of type 2 diabetes mellitus.
]. These findings suggest that diet may influence T2DM risk by influencing lipidomic sphingolipid intake and indirectly influencing bacterial production.In conclusion, dietary lipids and lipidomics seem to play a major role in glucose homeostasis, the development, and the progression of T2DM.
Furthermore, some studies in the literature suggest that diet may influence T2DM risk by influencing lipid metabolism and lipidomics and directly or indirectly influencing microbiota composition and forming metabolites because of microbiota modulation.
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Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain - Journal of Cannabis ResearchIntroduction Cannabidiol (CBD) is a potential therapeutic for pain management. Yet, there exists a dearth of studies of its tolerability and efficacy, especially in special populations. Former elite athletes are a special population both susceptible to chronic pain and also highly trained and attuned to assess medication tolerability concerns. The purpose of the present open-label pilot study was to assess the tolerability of CBD in this population. Materials and methods Retrospective analysis was conducted in deidentified data from 20 individuals who were all previously professional athletes in US/American football, track and field, or basketball, with careers ranging from 4 to 10 years. Participants received topical CBD (10 mg twice daily by controlled dispenser) for chronic pain resulting from acute lower extremity injuries. Assessments of tolerability and secondary analyses of pain, pain-related disability, and activities of daily living were collected by self-report over the 6-week study period. Data were analyzed by descriptive statistics, pairwise t-test, and linear regression. Results Seventy percent of participants completed the study. Of the individuals who completed the study, 50% reported minor adverse effects, none of which required medical attention, and 50% did not report any adverse effects. The mostly commonly reported effects were skin dryness (43% of study completers) and skin rash (21% of study completers), which rapidly resolved. There was a significant improvement in self-reported pain levels (intake mean 3.5 ± 0.29; exit mean 1.7 ± 0.23; P | 0.001) and pain-related disability, including family and home responsibilities, life support activities, occupational activities, recreational activities, self-care, sexual function, and social activities (all P | 0.001). Discussion To the best of our knowledge, this is the first study to assess CBD treatment in elite athletes, who are disproportionally susceptible to disabling injuries. Topical administra
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Sleep disturbances linked to increased risk of acute strokeIn a recent study published in the journal Neurology, researchers investigated how a wide range of symptoms of sleep disturbance, individually and cumulatively, could be associated with the risk of acute stroke.
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Air pollution lowers COVID-19 vaccine immune responseIn a recent study published in the journal Environmental Health Perspectives, researchers performed a population-level cohort study in Catalonia, Spain, to evaluate the association between exposure to air pollution for a prolonged duration and coronavirus disease 2019 (COVID-19) vaccine-induced antibody response.
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Air pollution linked to higher dementia ratesIn a recent article published in the British Medical Journal (BMJ), researchers at Harvard T.H. Chan School of Public Health presented the findings of a systematic review and meta-analysis that showed a link between air pollutants, especially particulate matter 2.5 (PM2.5) and clinical dementia. PM2.5 are fine air particles/droplets two and one-half microns or less in width.
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Study suggests potential therapeutic targets for COVID-19-related neurological pathologiesIn a recent study published in the journal Molecular & Cellular Proteomics, researchers analyzed the proteins in cerebrospinal fluid (CSF) samples obtained from African green monkeys and rhesus macaques infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 to understand the neurological manifestations of coronavirus disease 2019 (COVID-19).
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Alzheimer's risk patients may benefit from Mediterranean keto diet, study shows gut microbiome changesIn a recent study published in the Journal of the Alzheimer's Association (AA), researchers examined the effects of a low-carbohydrate-modified Mediterranean ketogenic diet (MMKD) on the gut microbiome and metabolome of patients at risk for Alzheimer's disease (AD).
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