The potential of Sofosbuvir against COVID-19 neurological symptoms PLOSBiology UCSanDiego COVID19 coronavirus covid symptoms neurology
By Dr. Priyom Bose, Ph.D.Nov 25 2022Reviewed by Benedette Cuffari, M.Sc. On 11th March 2020, the World Health Organization announced the global spread of the severe acute respiratory syndrome coronavirus 2 as the coronavirus disease 2019 .
One mouse model revealed that the SARS-CoV-2 spike S1 protein can cross the blood-brain barrier, thereby indicating that the virus can infect the brain and induce neurological symptoms. Autopsy reports of patients who died from COVID-19 showed the presence of SARS-CoV-2 in cortical neurons. Additionally, the possibility of vertical transmission of SARS-CoV-2 to the fetus has been found, which can affect fetal brain development.
These entry factor proteins are expressed at a reduced level in the CNS as compared to other organs. ACE2 and TMPRSS2, for example, are less expressed compared to NRP1, which is highly expressed in the cerebral cortex and hippocampus. However, BSG/CD147 gene is highly expressed in all brain regions.
Mechanistically, SOF inhibits HCV replication by restricting the activity of the ribonucleic acid -dependent RNA polymerase . A high degree of sequence and structural similarity was found between the RdRp of SARS-CoV-2 and HCV.
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