The potential effects of receiving 2 SARS-CoV-2 vaccine doses on household transmission in England CDCgov ucl SARSCoV2 vaccine vaccination transmission covid coronavirus covid
By Pooja Toshniwal PahariaDec 20 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Emerging Infectious Diseases, researchers assessed the effects of two-dose coronavirus disease 2019 vaccinations on household severe acute respiratory syndrome coronavirus 2 transmission among British residents.
HOSTED data of RT-PCR analysis-confirmed and LFD assay-confirmed COVID-19 cases reported to national surveillance systems were analyzed. Secondary COVID-19 cases were described as known household contacts of index COVID-19 cases with SARS-CoV-2-positive reports for samples obtained two days to two weeks following sample collection for the index case. The team excluded institutional, residential settings such as prisons and care homes. Cox regression modeling was used, and the HR were calculated after data adjustments for contact, socioeconomic status, and sex.
The median values for index case age and contact age were 35 and 32, respectively, and 51% and 49% of the corresponding participants were female. In total, 122,423 secondary COVID-19 cases among household contacts were analyzed. The majority of secondary COVID-19 cases were identified between February and May 2021, and most secondary COVID-19 cases were identified in households of non-vaccinated index COVID-19 cases.
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