Fat is a normal and necessary part of the body. Fat cells store and release energy, as well as play significant roles in hormonal regulation and immunity.
and diabetes—has focused scientific attention on the biology and chemistry of fat, resulting in a wealth of information about how fat cells work.Fat-filled lipid droplets, tiny spheres of fat many times smaller than, are a growing subject of scientific interest. Found inside many different cell types, these lipid particles have long been little understood.
The stakes of their findings are high: A ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer. "Imagine," adds Ivanovska,"trying to pop a balloon with your fist. Impossible. You can deform the balloon, but you won't puncture it. Now imagine trying to pop it with a pen. That's the difference between a fat cell and a cell with small fat droplets in the body. It's a fundamental physical difference, not a metabolic one."
"This isn't fat canonically conceived," says Tobin."This is about how fat works at scales smaller than a cell and poses physical risks to cellular components, even at the level of DNA."
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