The malaria pill hydroxycholoroquine failed to help coronavirus patients in 2 big studies
, found that among thousands of hospitalized coronavirus patients, those who received the antimalarial medication hydroxychloroquine didn't fare better or worse than patients who didn't receive the drug.
An observational study published Monday in JAMA examined 1,438 patients hospitalized between March 14 and 28 in New York state. It found that those who received hydroxychloroquine, the antibiotic azithromycin, or both hydroxychloroquine and azithromycin didn't have meaningfully lower rate of in-hospital deaths compared to patients who didn't receive the drugs. About 70% of hospitalized patients included in the study were given hydroxychloroquine alone or with azithromycin. , Business Insider's weekly newsletter on pharma, biotech, and healthcare.
The study also reported that cardiac arrest was more common in patients who received both hydroxychloroquine and azithromycin compared to those who received neither drug. In NEJM, an observational study looked at 1,376 patients admitted to Columbia University Irving Medical Center in New York City, 811 of who were given hydroxychloroquine.
The patients who received hydroxychloroquine tended to be more severely ill than those who did not receive the drug. Authors of both studies noted that randomized controlled trials — which assign patients either to the medication or a placebo control at random —are needed.
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