The FDA is inching closer to a long-term COVID booster plan

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The FDA is inching closer to a long-term COVID booster plan
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A team of advisors met Wednesday to discuss boosters, but left with more questions.

on April 6, a panel of independent scientific advisors to the Food and Drug Administration , debated the details of a plan for using vaccines to head off future waves of COVID, whether caused by an Omicron-like variant, or waning immunity from previous shots at a population level.

The agency came with two central questions: How should the country decide how often to deliver boosters, and when would vaccine manufacturers needed to update their formulations for evolving variants? The goal, FDA officials said, was to develop a COVID vaccination strategy that would be both consistent and understandable to the general public after a year ofMuch of the discussion centered on comparisons to influenza, a virus that’s fought with a continually updated and distributed vaccine.

Another key difference is that influenza is a winter virus, while SARS-CoV-2 has yet to exhibit a clear seasonal pattern. Chris Murray, director of the Institute for Health Metrics and Evaluation, said in a presentation that he expects another winter wave of COVID. But that’s based on a combination of factors like waning antibodies and the virus’ steady mutation, not just cold weather.

to the elderly in January 2022. That extra dose made recipients roughly 3.5 times less likely to experience severe disease, and half as likely to catch the virus—at the time, mostly Omicron—at all. Still, after eight weeks, recipients lost their resistance to infections. The results, which were also published inthis week, suggest that while more boosters could shield the vulnerable, they’re not likely to be effective at containing COVID spread.

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