The pointed pump counts Rihanna, Katie Holmes and Hailey Bieber as fans.
Coperni spring/summer 2023.
When it comes to styles, there are a wealth of options on offer. Bottega Veneta’s fiercely sharp pumps, as seen at Matthieu Blazy’s sophomore show, have been endorsed by Kendall Jenner and Sofia Richie, who wore them with a minidress and cropped jeans, respectively. As well as a streamlined upper, Blazy’s experimental silhouettes feature a jagged sculptural heel, which elevates their avant-garde appeal.Instagram: @DanixmichelleElsewhere, Marni’s metallic 5.
Still stuck on ballet flats? Consider Saint Laurent’s hybrid Blade slingback pumps – the pair Hailey Bieber has worn religiously this past month. As the name suggests, the house’s Blades are seriously pointy, but, unlike the aforementioned styles, their heel is a wearable 0.5cm. Take your pick.
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Meta-analysis of the effects of proton pump inhibitors on the human gut microbiota - BMC MicrobiologyMounting evidence has linked changes in human gut microbiota to proton pump inhibitor (PPI) use. Accordingly, multiple studies have analyzed the gut microbiomes of PPI users, but PPI–microbe interactions are still understudied. Here, we performed a meta-analysis of four studies with available 16S rRNA gene amplicon sequencing data to uncover the potential changes in human gut microbes among PPI users. Despite some differences, we found common features of the PPI-specific microbiota, including a decrease in the Shannon diversity index and the depletion of bacteria from the Ruminococcaceae and Lachnospiraceae families, which are crucial short-chain fatty acid-producers. Through training based on multiple studies, using a random forest classification model, we further verified the representativeness of the six screened gut microbial genera and 20 functional genes as PPI-related biomarkers, with AUC values of 0.748 and 0.879, respectively. Functional analysis of the PPI-associated 16S rRNA microbiome revealed enriched carbohydrate- and energy-associated genes, mostly encoding fructose-1,6-bisphosphatase and pyruvate dehydrogenase, among others. In this study, we have demonstrated alterations in bacterial abundance and functional metabolic potential related to PPI use, as a basis for future studies on PPI-induced adverse effects.
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