The midfielder pulled out of international duty with an injury and will miss Man United's return to Premier League action on Saturday.
Erik ten Hag has confirmed he will not have Sofyan Amrabat available for Saturday's Premier League clash against Brighton and Hove Albion.
"I think so, yeah," Ten Hag told MUTV when asked if the new signings will get a debut soon. "We are a little bit short of defenders, so [Reguilon] can come quickly. Ten Hag admitted in his pre-game press conference on Friday that both Mason Mount and Raphael Varane would also miss Saturday's clash through injury, however both Lisandro Martinez and Victor Lindelof are expected to be fit.
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