One child in Northern Ireland had to have a liver transplant after contracting the disease.
She said among the possible factors for the rise in cases is a link to adenovirus, a relatively common childhood infection.
"There are a range of other possible causes which are currently being investigated, including a number of other infections, as well as looking into toxins and environmental exposures," Dr Armstrong said. "We can confidently say that there is no link to the Covid vaccine as the vast majority of these children are too young to have been offered the vaccine.
"In terms of prevention, hand hygiene and respiratory hygiene are the most important methods of preventing and controlling the spread of the infections being investigated." Earlier this month, a child being treated for an acute form of hepatitis in the Republic of Ireland died.Both cases were linked to the unexplained type of hepatitis being reported in children.
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