Substance use disorder may be connected to a specific brain circuit

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Substance use disorder may be connected to a specific brain circuit
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The network includes five primary areas of the brain and could inform future clinical treatments that previously generally targeted regions.

used that data to evaluate this newly discovered brain circuit and areas where the brain had atrophied, or shrunk. It evaluated data from 144 studies on addiction and found that abnormalities across substance use disorder are in a common brain network. The studies primarily looked at alcohol, cocaine, heroin, or nicotine addiction.

“Our study found that different brain regions implicated in addiction are all a part of a common brain circuit,” study co-author Michael Fox, founding director of the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital,. “Consistency across different papers means we now have a brain circuit to target addiction with treatments, rather than just a region.” The team reviewed data involving more than 9,000 participants.

The circuit involves five primary areas of the brain–the anterior cingulate, insula, dorsolateral prefrontal cortex, thalamus, and“The five regions that pop up are places that actually do make some amount of intuitive sense. The medial prefrontal cortex goes right down to your brain and it’s important because it’s been a target for successful nerve stimulation trials,” says Stubbs.Laura Baisas

Laura is a science news writer, covering a wide variety of subjects, but she is particularly fascinated by all things aquatic, paleontology, nanotechnology, and exploring how science influences daily life. Laura is a proud former resident of the New Jersey shore, a competitive swimmer, and a fierce defender of the Oxford comma.Sign up to receive Popular Science's emails and get the highlights.

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