Researchers at Boston Medical Center and Dana-Farber Cancer Institute have conducted one of the first-ever analyses of neuroendocrine tumors (NETs) at single-cell resolution, unlocking new insights into this rare and often hard-to-treat cancer. The findings represent a tremendous leap forward in understanding why these tumors are largely resistant to immunotherapy and provide key insights that could lead to future treatments.
, pancreas, and lung. Despite new forms of treatment, the tumors remain difficult to treat and are largely resistant to immunotherapy, which has revolutionized treatments for other cancers. In part, the reason for this challenge is that the understanding of the underlying biology of NETs was incomplete.
"This study provides remarkable insights about the heterogeneity of neuroendocrine tumors and the tumor and immune microenvironment," said Jennifer Chan, MD, MPH, Clinical Director, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute."We are currently building on this work with the aim to discover new therapeutic strategies that will advance the care of patients with neuroendocrine tumors.
Through this study, researchers sought to understand both the tumors themselves and the surrounding cells in the tumor microenvironment. Leveragingsequencing allowed for an unprecedented view of the genes and signaling pathways that are involved in tumor progression and potential response to immunotherapy.
The team uncovered previously unappreciated heterogeneity within neuroendocrine tumor subtypes and revealed potential evolution in tumor characteristics as they metastasize. At that resolution, they were also able to observe cells and related proteins in that microenvironment that suppress immune responses. Targeting those proteins could render these tumors more responsive to immunotherapy treatment.Samantha E.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Boston leaders to discuss crisis at Mass. and Cass during Tuesday hearingBoston city leaders are set to discuss the ongoing situation at Mass. and Cass — the intersection at the crossroads of the South End, Southie and Roxbury that has long been the epicenter of the region’s addiction and homelessness crises. Boston City Council’s Committee on Public Health, Homelessness and Recovery will hold a hearing on the area on Tuesday afternoon,…
Consulte Mais informação »
Cannabis farm discovered as crews tackle Boston fireAround 100 cannabis plants were located across three floors of the building, police say.
Consulte Mais informação »
Fishermen say they found man who fell from oil tanker in ocean off Boston coastLocal fishermen pulled a man from the ocean far off the coast of Boston early Tuesday morning after he fell from an oil tanker, the crew told NBC10 Boston. The vessel raced back to shore to get the man to a hospital, according to the crew. Mayday calls for a man overboard were heard about 4:30 a.m. from the oil…
Consulte Mais informação »
Boston NBC, Telemundo stations announce $225,000 in grants to six local nonprofitsNBC10 Boston, Telemundo Boston, and the Comcast NBCUniversal Foundation announced Tuesday that six local nonprofits will receive a combined total of $225,000 in unrestricted grants. The grants are part of the NBCUniversal Local Impact Grants program and are given to nonprofit organizations that are helping to improve their local communities with unique and innovative programming in three grant categories including Next Generation Storytellers, Youth Education & Empowerment, and Community Engagement. Nationwide this…
Consulte Mais informação »
Boston City Council elections: The battle for District 5A historic race is unfolding in Boston City Council’s District 5. Incumbent Ricardo Arroyo was ousted by voters in September’s preliminary election, leaving Enrique Pepén and José Ruiz on the November ballot. “I applaud them for wanting change,” said Ruiz speaking about District 5 voters. “It came to fruition and the hard work paid off,” said Pepén. The pair come…
Consulte Mais informação »