Study identifies two novel highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 CDCgov avianinfluenza avianflu virus H5N1 novel viral zoonotic transmission swans
By Pooja Toshniwal PahariaMay 16 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Emerging Infectious Diseases Journal, researchers investigated the genetic origin, distribution patterns, and antigenicity of two deceased migrating swans from China infected with the H5N1 novel avian influenza viruses .
Thus far, at least four waves of H5 virus transmission have occurred: 2.2 clade H5N1 viruses between 2005 and 2006, H5N1 2.3.2.1c clade H5N1 viruses between 2009 and 2010, 2.3.4.4a clade H5N8 clade and 2.3.2.1c clade H5N1 viruses between 2014 and 2015, and 2.3.4.4b clade H5Ny viruses between 2016 and 2017.
About the study In the present study, researchers reported on H5N1 clade 2.3.4.4b reassortment among the migrating avian population of China. The team reconstructed Bayesian time-resolved phylogenetic origin trees for all three H5N1 viral isolate genes based on the National Centre for Biotechnology Information and GISAID references.
The H5N1 strains induced severe histopathologic alterations among wild avian species, characteristic of HPAIVs, including numerous basic-type amino acid molecules at the site of HA breakdown. Bs/EC/74-Lg/2021 clustered with H5N1 influenza viruses originating from South Korea and Japan in the second cluster, with 99.0% to 100.0% identical sequences.
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