Study highlights the importance of bivalent mRNA booster vaccination in populations at high risk of severe COVID-19 TheLancetInfDis bivalent vaccine booster highrisk patients covid COVID19 SARSCoV2
By Neha MathurApr 17 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Lancet Infectious Diseases Journal, researchers performed a population-based, retrospective cohort study in Israel using electronic health records data from Calit Health Services .
However, against the Omicron variant, the efficacy of monovalent mRNA vaccines was relatively less compared to earlier SARS-CoV-2 variants, e.g., Delta. Also, it waned rapidly between three to four months after vaccination. However, there is a shortage of randomized controlled trials clinically evaluating bivalent mRNA booster vaccines, which are urgently needed to establish they prevent severe COVID-19 outcomes.
The primary study outcome was COVID-19-related hospitalization, which the team compared among participants who received a bivalent mRNA booster vaccination vis-à-vis those who did not receive it. According to the authors, many factors drove its low uptake, including a shortage of data on their efficacy against severe COVID-19, reports of adverse side effects, or the notion that the vaccine was unnecessary and infection helped elicit adequate immunity.
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