Using Painkillers Like Ibuprofen May Worsen Joint Inflammation in Knees, Study Says
Researchers set out to see how NSAIDs impact synovitis, the inflammation of the membrane lining the joint that has been found to play a role in progressing osteoarthritis. They planned to examine patients who experiencetaking these medications over time. They followed 277 participants from the Osteoarthritis Initiative Cohort with moderate to severe osteoarthritis who used NSAIDs as their treatment for at least one year between baseline and a four-year follow-up.
All participants in the study had an MRI of the knee, initially and during a four-year follow-up, to track cartilage thickness, composition, and other measurements to evaluateprogression. The scientists found that long-term use of NSAIDs had no benefit, and joint inflammation and cartilage quality were worse at a four-year follow-up, compared to the control group.
Painkillers are a common at-home treatment used to ease aches and pains from osteoarthritis, which is the most common form of arthritis. It affects more than 32 million adults in the U.S. and more than 500 million people worldwide, according to the press release. People most often experience pain in their hands, hips, and knees when the cartilage that cushions the joints wears away, causing inflammation and swelling.
“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down the progression of osteoarthritis of the knee joint,” Dr. Luitjens said in the press release. “The use of NSAIDs for their anti-inflammatory function has been frequently propagated in patients with osteoarthritis in recent years and should be revisited since a positive impact on joint inflammation could not be demonstrated.
, which could potentially lead to the worsening of synovitis. But, she noted that her research did adjust for physical activity in results. Additionally, it could simply be that though NSAIDs have anti-inflammatory effects, they cannot prevent synovitis. She added that more research is needed in the future.
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