In vitro fertilization (IVF) is a time-intensive and often stress-inducing fertility procedure. Yet how does that stress impact its success? Investigators at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, assessed the effects of anxiety and depression in men on fertility and IVF outcomes.
Reviewed by Megan Craig, M.Sc.Oct 18 2023 Their findings reveal no correlation between anxiety, regardless of antidepressant use, on IVF outcomes or live birth rate. Results are published in Human Reproduction.
Zachary Walker, MD, reproductive endocrinology and infertility fellow in the Center for Infertility and Reproductive Surgery at the Brigham Results indicated that 22.5% of respondents experienced anxiety and 6.5% experienced depression, according to HADS scores. There was no notable difference in live birth rates between those with and without anxiety, though men with anxiety had, on average, lower total motile sperm counts during egg retrieval. Walker and the team found that IVF outcomes and live birth rates were unaffected by antidepressant use.
Related StoriesThe study's limitations included an inability to assess sperm morphology at time of egg retrieval and to evaluate the full impact of depression scores on fertility due to the small portion of participants with high depression scores. Researchers also could not fully assess all patients' hormone levels – something they aim to investigate with future studies.
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Study finds men's antidepressant use doesn't negatively impact IVF successIn vitro fertilization (IVF) is a time-intensive and often stress-inducing fertility procedure. Yet how does that stress impact its success? Investigators at Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, assessed the effects of anxiety and depression in men on fertility and IVF outcomes.
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