Squid and human brains develop the same way despite diverging 500 million years ago

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Squid and human brains develop the same way despite diverging 500 million years ago
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It seems that the blueprint for complex brain development remains the same, despite 500 million years of divergent evolution.

Scientists who watched nerve cells connect inside the eyes of growing squid have uncovered a remarkable secret — the cephalopods’ brains independently evolved to develop in the same way ours do.

The intelligence of cephalopods — a class of marine animals that includes octopuses, squid and cuttlefish — has long been a subject of fascination among biologists. Unlike most invertebrates, these animals possess remarkable memories; use tools to solve problems; excel at camouflage; react with curiosity, boredom or even playful malevolence to their surroundings; and can dream, if the ripples of colors that flash across their skin as they sleep are any indication.

To study the squid embryos’ developing brains, the scientists used fluorescent dyes to mark a special type of stem cell called neural progenitor cells, before studying how they developed with regular, 10-minute snaps from microscope cameras. The cameras looked at the retinas, where roughly two-thirds of a squid's neural tissue is found.

Just as in vertebrates, the researchers saw the squids’ progenitor cells arrange themselves into a structure called a pseudostratified epithelium — a long, densely packed structure that forms as a crucial step in the growth of large, complex tissue.

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