Antibody molecules may travel up nerve fibres that pass from the nose to the brain in experiments on rats20
in rats by stopping blood from flowing to parts of their brains. This meant the animals became clumsier at reaching through a hole for food pellets, something they could do easily beforehand.
In rats that received a nasal spray of antibodies once daily for two weeks, their success at this task improved to about 60 per cent of their former ability by four weeks after their injury. In animals given a placebo treatment, the figure was about 30 per cent. When Schwab’s team examined the rat brains, they found that the treated rats had sprouted more new nerve fibres. “We have reached a level of antibodies that is effective in repairing a large stroke lesion,” says Schwab. “It shows there’s a natural regenerative power within the brain and you just have to take the brakes off to let it happen.”at Newcastle University, UK, says any way of getting drugs into the brain would have wide benefits.
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