Researchers from UCL, Great Ormond Street Hospital, and the Wellcome Sanger Institute have unveiled findings that shed light on why certain children experience extended remission after undergoing cutting-edge CAR T-cell therapy for leukaemia. The joint research initiative, recently published in N
have unveiled findings that shed light on why certain children experience extended remission after undergoing cutting-edge CAR T-cell therapy for leukaemia., merges cutting-edge immune therapy design knowledge with state-of-the-art computational analysis to identify a genetic signature of CAR T-cells that will be the most effective in the long term.
This work provides the first stepping stone in understanding why some CAR T-cells persist. The team aims to build on the signature discovered in this project to identify key markers in cell populations and ultimately understand if there is a way to spot, or even create CAR T-cells that will persist long-term before treatment begins.
Dr. Sara Ghorashian, co-senior author, Consultant in Paediatric Haematology at GOSH, and Honorary Senior Clinical Lecturer at the UCL GOS ICH, said: “This data for the first time shows us the characteristics of long-lasting CAR T-cells which are responsible not just for curing children with ALL in our study but also seen in adults treated with a different CAR T-cell product for a different type of leukemia.
As part of the study, the researchers identified the key genes in CAR T-cells that appeared to enable them to persist in the body for a long time. Importantly these genes will provide a starting point for future studies to identify markers of persistence in CAR T-cell products as they are made and ultimately improve their effectiveness.
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