Although several medications are approved to treat attention-deficit/hyperactivity disorder (ADHD), some individuals experience limited benefits from the drugs or develop side effects from their use.
Reviewed by Lily Ramsey, LLMOct 9 2023 A recent clinical trial published in the Journal of Clinical Psychiatry by investigators at Massachusetts General Hospital , a founding member of Mass General Brigham , has demonstrated that the drug solriamfetol may be an effective alternative for managing ADHD in adults.
To test the potential of solriamfetol for treating ADHD, researchers randomized 60 adults with the condition to solriamfetol or placebo for 6 weeks. Participants were interviewed serially using the primary outcome measure for the trial, the Adult ADHD Investigator Symptom Rating Scale . ADHD symptoms were further evaluated by a patient-reported measure.
Solriamfetol had no significant effect on sleep quality as evaluate by the Pittsburgh Sleep Quality Index, or on average heart rate or blood pressure. Adverse experiences that occurred at a higher numerical rate than placebo fell under the categories of decreased appetite, headache, gastrointestinal symptoms, insomnia, increased energy, cardiovascular and neurologic effects.
Craig B.H. Surman, MD, lead author, Director of the Clinical and Research Program in Adult ADHD at MGH and Associate Professor of Psychiatry at Harvard Medical School
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