Small molecule inhibitors show early-stage promise against YAP fusion-driven cancers naturecellbio
, come from a team led by co-first authors Xiaohua Hu, Ph.D., and Xiaoping Wu, Ph.D., and corresponding author Qing Richard Lu, Ph.D., scientific director of the Brain Tumor Center. The work also includes contributions from 15 co-authors based in Cincinnati, Cleveland, Seattle, Shanghai, China, and Warsaw, Poland.
Adults usually experience these tumors developing along the spinal cord, and in many cases, they can be removed with surgery. Overall, the five-year survival rate for this type of cancer is nearly 84%, according to the National Cancer Institute and the American Society of Clinical Oncology.are high for tumors that can be removed surgically, about one-third of children with EPN experience relapses despite surgery, radiation, and chemotherapy. For these children, relapse is nearly always fatal.
But in recent years, scientists have discovered an entire family of YAP proteins that arise from YAP1 fusions with other genes in ways that promote even more aggressive cancer tumor growth. YAP fusion proteins have been detected in subtypes of skin cancer,The new study reveals that YAP fusion proteins disrupt the body's cancer defenses in a different way than many scientists had thought.
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