Here's what experts have learned about the time between the Pfizer and Moderna shots and how that affects overall protection.
“Even four weeks made a difference as opposed to having three weeks between doses,” Gandhi said.
The vaccine efficacy against symptomatic illness “is lower in Israel and the U.S. and both countries opted for a three-week strategy for Pfizer, whereas Canada and the U.K. both have not reported reduction in vaccine effectiveness against symptomatic COVID,” Gandhi said.Experts are anaylzing real-world data from Canada and the U.K., where vaccine scarcity forced people to separate their doses up to four months.
This idea of extending the time between doses is not an accident, Bogoch said. “People will form a more robust immune response with the doses separated apart,” he explained. Bogoch added it’s not unreasonable, given the circumstances, that the doses for the COVID-19 vaccines were separated by a narrow 21 to 28 days. If we had separated doses by several months, it would have taken much longer to conduct the clinical trials and then vaccinate people and build up population immunity all in the midst a global public health crisis.
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