Shoot the messenger: RNA editing is here
— RNA molecules with catalytic activities — for RNA-guided trans-splicing of targeted RNA sequences in vitro and in. “These catalytic RNAs don’t come from mammalian systems,” says Sullenger, who is at Duke University. “In evolution, a lot of the [catalytic] functions have been replicated by proteins.
Seong-Wook Lee, a former postdoctoral researcher in Sullenger’s lab, continued the work in his native South Korea, and Rznomics has emerged to take it into the clinic but with the emphasis switched to cancer. Rznomics’ lead program, RZ-001, for which it has received FDA clearance to conduct a US clinical trial for liver cancer, is designed to sensitize to ganciclovir cancer cells that overexpress human telomerase reverse transcriptase.
Unlike ADAR-based editing, which is limited to single-base A-to-I substitutions, both Ascidian’s and Rznomics’ approaches enable large-scale changes to be introduced in a mature mRNA transcript. “ADAR is like fixing typos. The splicing approaches are rewriting paragraphs,” says Sullenger.
Even if ADAR-based editing firms are limited to making single-base changes, the resulting biological consequences can be large. Modulating the levels of a transcription factor by increasing its half-life by even 10% can have a significant effect, Aiyar says. Introducing a dominant negative mutation to a protein can also have an outsized effect, Platenburg says. With the notable exception of AATD-directed therapies, most ADAR-based programs remain under wraps for now.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Trans-segmental imaging in the spinal cord of behaving mice - Nature BiotechnologyA wearable macroscope enables cellular imaging across multiple spinal segments in behaving mice.
Consulte Mais informação »
Microfluidics-free single-cell genomics with templated emulsification - Nature BiotechnologyA microfluidics-free, scalable single-cell RNA-sequencing method produces high-quality transcriptomes.
Consulte Mais informação »
High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE - Nature BiotechnologyCytoSPACE maps individual cells from a reference single-cell RNA sequencing atlas to spatial transcriptomics data.
Consulte Mais informação »
JPMorgan says this biotechnology stock can rally nearly 50% because of its drug pipelineDespite cutting $1 off the price target, the firm still expects the stock to rally nearly 49%.
Consulte Mais informação »
Two suspects shoot robbery victim and flee on foot as getaway car stalls: policeA man was shot in the arm after confronting two suspects that robbed a convenience store in Houston, Texas. Authorities are still searching for the two suspects.
Consulte Mais informação »
Chief: Frederick police fatally shoot man with knifePolice in Frederick, Maryland, fatally shot a knife-wielding man after he ignored officers’ commands to drop the weapon, according to the city’s police chief and the office of the state attorney general.
Consulte Mais informação »