The fight against coronavirus is on.
to identify the shared genes. During the analysis, the team of researchers led by Anurag Verma collected genotypic information from electronic health record data of more than 650,000 U.S. veterans. This information enabled the scientists to find the links between gene variants responsible for COVID-19 severity in veterans and the gene variants that led to several other medical conditions in humans.
Strong genetic links were discovered for gene variants related to type-2 diabetes, venous thromboembolism , and ischemic heart disease. Interestingly, the first and last disorders are well-known COVID-19 risk factors . According to the researchers, other disorders that share genetic links with COVID-19 severity are chronic alveolar lung disease , idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease . The PheWAS analysis revealed that the shared genes are also associated with neutropenia in veterans having African and Hispanic ancestry. Surprisingly, such genetic links were not found in veterans of European ancestry.
An interesting finding from the analysis was that some of the shared variants responsible for intense COVID-19 sickness actuallysuch as psoriasis and lupus in humans.
“The study demonstrates the value and impact of large biobanks linking genetic variations with EHR data in public health response to the current and future pandemics. MVP is one of the most diverse cohorts in the US. We had a unique opportunity to scan thousands of conditions documented before the COVID-19 pandemic. We gained insights into the genetic architecture of COVID-19 risk factors and disease complication,” said Anurag Verma, lead researcher.
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