High-calorie foods—high in fat, oil, and sugar—often taste delicious but can also cause overeating, leading to obesity and major health problems. But what stimulates the brain to cause overeating? Recently, it has become clear that a gene called CREB-Regulated Transcription Coactivator 1 (CRTC1)
Obesity is a growing global health concern, affecting millions of people worldwide. One of the major contributors to obesity is the consumption of high-calorie foods.
Recently, it has become clear that a gene called CREB-Regulated Transcription Coactivator 1 is associated with obesity in humans. Studies on mice have shown that deleting CRTC1 results in obesity, suggesting that its presence suppresses the condition. However, the specific neurons responsible for suppressing obesity through CRTC1 and the mechanism behind it are still unknown, as the gene is expressed in all neurons in the brain.
To elucidate the mechanism by which CRTC1 suppresses obesity, a research group led by Associate Professor Shigenobu Matsumura from the Graduate School of Human Life and Ecology at Osaka Metropolitan University focused on neurons expressing the melanocortin-4 receptor . They hypothesized that CRTC1 expression in MC4R-expressing neurons suppressed obesity because mutations in the MC4R gene are known to cause obesity.
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