Scientists make breakthrough for 'next generation' cancertreatment uniofeastanglia nchembio
reveals the science behind this innovative idea. It shows how the UEA team have engineered antibody fragments—which not only"fuse" with their target but are also light activated.
The principal scientist for this study, Dr. Amit Sachdeva, from UEA's School of Chemistry, said,"Current cancer treatments like chemotherapy kill cancer cells, but they can also damage healthy cells in your body such as blood and skin cells. This means that they can cause side effects including, feeling tired and sick, and they also put patients at increased risk of picking up infections.
"Several antibodies and antibody fragments have already been developed to treat cancer. These antibodies are much more selective than the cytotoxic drugs used in chemotherapy, but they can still causeNow, the UEA team has engineered one of the first antibody fragments that binds to, and forms a covalent bond with, its target—upon irradiation with UV light of a specific wavelength. Dr. Sachdeva said,"A covalent bond is a bit like melting two pieces of plastic and fusing them together.
to be more efficient and targeted because it means that only molecules in the vicinity of the tumor would be activated, and it wouldn't affect other cells.for patients, and also improve antibody residence time in the body. It would work for cancers like skin cancer, or where there is a solid tumor—but not for blood cancers like leukemia.
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