Scientists identify potential new 'soldier' for cancer immunotherapy
Despite the success of immunotherapy in helping many people with cancer, the majority of patients still do not respond to these treatments. There is need for continued research.On April 20, 2022, researchers at the Sloan Kettering Institute reported in the journalthat a recently discovered new immune cell"soldier" could be a good target for immunotherapy, raising hopes that it might help narrow the gap between people who respond and those who do not.
They made several startling discoveries. For one, killer innate-like T cells don't make the immune checkpoint molecule PD-1 and, as a consequence, do not appear to become exhausted the way typical killer T cells do. This is an attractive feature in a potential immune cell therapy. Lastly, unlike conventional T cells, they don't recirculate throughout the blood and lymph fluid, making stops in lymph nodes. Rather, they appear to home directly to tissues throughout the body, where they seek out danger.All of these make them of particular interest as a target of immunotherapy, Dr. Li says.
Because IL-15 isn't highly produced in healthy tissues, the killer innate-like T cells would not be spurred into action there, and therefore would not cause unwanted damage.
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