They used DNA from 3,600 people to figure out how we're all related. 🧬 engineering
, a postdoctoral researcher at the Broad Institute of MIT and Harvard and first author, tells IE.
While the first genome sequenced came from an anonymous donor, that sequence of base pairs is 99.9 percent identical to every other person's genome. That's because"we're ridiculously [closely related] compared to almost all other mammals," Fuentes says.Some of that overlap enables fundamental biological processes that are shared widely across the entire tree of life. That's why we share about 35 percent of our genome with daffodils.
No matter how different two siblings might be, side-by-side analysis of their genomes would show that it takes just two ancestors — their parents — to account for the differences between the two samples.In the new paper, researchers did something similar, but for more than 3600 people."We have algorithms that look at those patterns of genetic variation and reconstruct who the ancestors [must've been] that generated that pattern of variation," he says.
The team turned to data about where and when the samples had come from to estimate where and when specific ancestors with particular genomes had lived. For some, it might have been 500 years ago. For others, it was more like 500,000 years.In the end, the researchers needed to infer the existence of 27 million people to explain the patterns of genetic variation in their 3609 samples.
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