A single administration of the mutant anti-aging gene stopped the decay of heart function in middle-aged mice.
Researchers at the University of Bristol and the MultiMedica Group in Italy discovered a certain gene in a population of centenarians that has helped keep their hearts young by protecting them against diseases linked to aging, such as heart failure.. Blue zones are regions in the world where people are speculated to live longer than average. They include Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; Icaria, Greece; and Loma Linda, California, United States.
The three-year study was also performed in test tube human cardiac cells in Italy. Researchers from the MultiMedica Group in Milan led by Professor Annibale Puca administered the gene in heart cells from elderly patients with severe heart problems, including"The cells of the elderly patients, in particular those that support the construction of new blood vessels, called 'pericytes,' were found to be less performing and more aged.
"Our findings confirm the healthy mutant gene can reverse the decline of heart performance in older people. We are now interested in determining if giving the protein instead of the gene can also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a treatment based on a protein is safer and more viable than gene therapy," said Professor Madeddu.
"We have a new confirmation and enlargement of the therapeutic potential of the gene/protein. We hope to test its effectiveness soon in clinical trials on patients with heart failure," added Puca, Head of the laboratory at the IRCCS MultiMedica and Professor at the University of Salerno.The aging heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt.
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