A multi-gene expression signature in tumors is associated with aggressive disease and poor patient outcomes, and it has the potential to become a genetic cancer biomarker. The human cell's primary source of energy, the mitochondria plays an important role in the metabolism of cancer cells. In a s
As of 2022, it is estimated that over 600,000 people die of cancer each year in the United States.
The human cell’s primary source of energy, the mitochondria plays an important role in the metabolism of cancer cells. In a study recently published in, researchers from throughout the world, including Dario C. Altieri, M.D.
Andrew Kossenkov, Ph.D., first author on the paper, assistant professor in Wistar’s Gene Expression and Regulation program, and scientific director of the Institute’s Bioinformatics Facility, shares, “After original findings on the strong association of Mic60 in low levels in cancer tissues, we were curious if we could identify a small panel of Mic60 downstream genes of specific functions and if the Mic60-low gene panel signature has clinical relevance – i.e.
“Gene signatures can be used to gain insight into specific tumor qualities,” Kossenkov explains. “If extensively developed, tested, and validated, this [Mic60-low gene signature] can be a potential simple point-of-service molecular tool for pancreatic cancer prognosis or stratification of patient risks and prediction of treatment response.”
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