The gene-editing technology CRISPR could knock out a protein that's the major source of cat allergies, a new study says.
Researchers at the Virginia-based biotech company InBio have been working on their own approach. They’re hoping to use CRISPR, the Nobel Prize-winning gene editing tech, to produce cats that simply make little to no Fel d 1. In their latest research,Monday in The CRISPR Journal, they say they’ve collected evidence that this can be done effectively and safely.
Analyzing the DNA of 50 domestic cats, they found regions along two genes primarily involved in producing Fel d 1 that would be suitable for editing with CRISPR. When they compared the genes of these cats to those from eight wild cat species, they also found that there was a lot of variation between the groups. That could indicate, as other research has suggested, that Fel d 1 is non-essential to cat biology and can thus be eliminated without any health risks.
All in all, the researchers say that their findings show that “Fel d 1 is both a rational and viable candidate for gene deletion, which may profoundly benefit cat allergy sufferers by removing the major allergen at the source.”
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