Nature research paper: SARS-CoV-2 Omicron boosting induces de novo B cell response in humans
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses and the development of new variant-derived vaccines5–9
. It remains unclear, however, whether the additional doses induce germinal centre reactions where reengaged B cells can further mature and whether variant-derived vaccines can elicit responses to variant-specific epitopes. Here, we show that boosting with either the original monovalent SARS-CoV-2 or bivalent B.1.351/B.1.617.2 mRNA vaccines induces robust spike-specific GC B cell responses in humans.
Wafaa B. Alsoussi, Sameer Kumar Malladi, Julian Q. Zhou, Baoling Ying, Wooseob Kim, Aaron J. Schmitz, Tingting Lei, Stephen C. Horvath, Alexandria J. Sturtz, Katherine M. McIntire, Birk Evavold, Suzanne M. Scheaffer, Isabella F. Fox, Senaa F. Mirza, Christopher W. Farnsworth, Michael S. Diamond, Jackson S. Turner & Ali H. EllebedyZhuoming Liu, Baoling Ying, Suzanne M. Scheaffer, Sean P. J. Whelan & Michael S.
Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USAModerna, Inc., Cambridge, MA, USAInfectious Disease Clinical Research Unit, Washington University School of Medicine, St. Louis, MO, USADivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USAMallinckrodt Institute of Radiology, Washington University School of Medicine, St.
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