The no-frills carrier says its new forecasts are based on the assumption that there is no fresh disruption caused by COVID and the state of the war in Ukraine.
Ryanair has raised its annual profit guidance, saying it enjoyed a better Christmas season than expected but noted a"recent softening" in flights from the UK.
The no-frills airline said on Wednesday evening that it had hiked its full year profit after tax expectations from a range of €1bn-€1.2bn to €1.325bn-€1.425bn.said, which were expected to deliver €200m in profits in its third quarter to the end of December.The company - Europe's largest airline by passenger numbers - explained that it was expecting January-March to be loss making, largely due to the absence of Easter during the financial year because it falls in April 2023.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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Hospital told staff to return bonuses for picking up shifts day before ChristmasNHS staff working at a Buckinghamshire hospital have been left angry after being told to pay back their Christmas bonuses.
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LadBaby's Christmas number one Food Aid falls 84 places on chart in one weekLast week, LadBaby broke a new UK chart record as they became the first act in history to achieve five Christmas number ones. But just one week later, it's suffered a hefty drop 😬
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Petrol stations 'cashed in' on Christmas rail strikes in 'fuel sales bonanza', AA claimsThe cost of filling a 55-litre car came to around £85 in London and the South East on Boxing Day, compared to just over £79.50 in Northern Ireland, according to AA figures
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