Researchers Have Flipped the Script on Autism Genetics — Researchers from Cold Spri |
A recent study has found that siblings affected by autism inherit a greater proportion of their genetic material from their father rather than their mother.autism spectrum disorderFor many years, scientists believed that siblings diagnosed with ASD tended to inherit more genetic traits from their mother than their father.
“There are children diagnosed with autism who are high functioning,” Iossifov says. “They have a completely productive life, although they have some minor troubles in social interactions, as most of us do. But also, there are children diagnosed with autism who never learn to speak, and they have definitely a difficult life.”
Over the last two decades, CSHL scientists have led a multimillion-dollar effort to uncover the genetic origins of autism. They discovered thousands of genes that, when damaged, may cause a child to be born with ASD. But their work was not able to account for all cases of ASD. So Iossifov and Wigler set out to find the missing sources.
No one is sure how dad’s genome makes its mark on children with ASD. But Iossifov has a couple of interesting ideas. He thinks some fathers may carry protective mutations that fail to get passed on. Or fathers may pass down mutations that trigger the mother’s immune system to attack the developing embryo. Both theories offer hope for parents of children with ASD and other neurological disorders like schizophrenia.
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