A team of researchers connected with Harvard Medical School has found a genetic link to rare reaction to pet germ.
In this Aug. 2, 2018 file photo provided by Dawn Manteufel, Greg Manteufel lays in his hospital bed at Froedtert Hospital in Milwaukee. He lost parts of his arms and legs, as well as the skin of his nose and part of his upper lip from capnocytophaga, a bacteria commonly found in the saliva or cats and dogs which almost never leads to people getting sick, unless the person has a compromised immune system. Manteufel was perfectly healthy when he got sick in June of 2018.
The case is extremely rare and doctors at his hospital, Froedtert & the Medical College of Wisconsin, had no explanation for why he got so sick. But over the last 10 years there have been at least five other healthy people who have had severe reactions to the germ. A team of researchers connected with Harvard Medical School has developed a theory on why — a gene change in all the victims.
And so he persisted, through more than 20 surgeries, including amputations of his left and right arms just below the elbow, and legs through the middle of the knee.“Greg said he didn’t come this far to lay down and let this beat him,” Dawn Manteufel said. The team has done genetic testing on five otherwise healthy people who suffered capnocytophaga infections to see if they could find anything in common. They discovered all had a gene connected to the immune system that was working differently — a genetic variant.
Of the five in the study, three survived with amputations and two did not. Fieg hopes their research can determine why some did not survive. Plastic surgeons plan another surgery to perfect his nose. They’ve already moved skin from his forehead there. It looks oversized now, but it will eventually fit in with the rest of his face.
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