Researchers have found evidence of inherent changes to the pancreas in people with type 1 diabetes. Published recently in Scientific Reports, these new findings help explain how low blood glucose occurs in type 1 diabetes.
Schematic of RAGE as an α cell sensor that regulates the expression of glucagon. In non-diabetic conditions, glucagon expression leads to increased blood glucose levels, which generates AGEs, thereby binding and upregulating RAGE. Then, RAGE signaling suppresses further glucagon expression, decreasing blood glucose levels, AGEs and RAGE expression. In type 1 diabetes, resting hyperglucagonemia leads to hyperglycemia, excessive AGEs, excessive RAGE binding and its upregulation.
"To study if there was a role for RAGE in low blood glucose or hypoglycemia, we used pancreatic tissue samples that were generously donated byDr. Leung said that this was an exciting result that supported an increasing body of scientific evidence showing that there are inherent changes to the pancreas in type 1 diabetes.
"However, this paper provides further evidence that changes in the pancreas itself may contribute to the hallmarks of the disease, such as hypoglycemia." "This can lead to irritability, trembling and falling unconscious, requiring immediate medical attention," Professor Forbes said.
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