Cas13 variants with minimal collateral effect are expected to be more competitive for in vivo RNA editing and future therapeutic applications, researchers claim.
The new approach using the Cas13 enzyme, targeting RNA, is safer because RNAs are transient molecules that only exist in the cell for a short period of time and are not integrated into the genome, the researchers claimed.
CRISPR-associated protein-9 is an enzyme that can cut the two strands of DNA in the genome to add or remove material in the most widely used system. "CRISPR-Cas9 and Cas9-based gene editing tools are well protected by patents. Other companies don't have a chance [to develop them]," Hui told Bioworld, a WeChat official account focusing on research.
"The CRISPR-Cas13 systems are more specific and precise, so they have a broader scope of application." However, the enzyme's ability to cleave non-target RNAs, or collateral cleavage, limits its clinical application.
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