A research team led by University of California, Irvine scientists has developed an innovative method for quickly and efficiently creating vast collections of chemical compounds used in drug discovery by harnessing the power of ribosomes, the molecules found in all cells that synthesize proteins and peptides.
describe this transformative technique, which could replace the current manually intensive process, accelerating the discovery of new drugs that could affect treatment of a wide array of diseases and conditions.
Chemical libraries are collections of molecules that are screened to identify those with promising activity or therapeutic potential. Screening involves asking the same biological question of each chemical in the library in the form of a rapid experiment or assay. "Library synthesis and screening are the first steps in the discovery of new medicines," said Brian M. Paegel, UCI professor of pharmaceutical sciences and the study's co-corresponding author."This new technology allows us to synthesize libraries of ultra-miniaturized gel beads that each contain hundreds of thousands of copies of a single compound from the library.
The team invented a novel approach to generate gel beads that are roughly the size of a human cell, each containing vast quantities of ribosomes, an enzyme called RNA polymerase and a magnetic core adorned with DNA, not unlike a human cell's nucleus. The DNA cores encode—or provide assembly instructions for—specific peptide molecules. Insulin is an example of a naturally occurring peptide that has become a drug.
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